Alterations in aldosterone biosynthesis in essential hypertensives.
نویسندگان
چکیده
منابع مشابه
Alterations in aldosterone biosynthesis in essential hypertensives.
We studied hypertensives with decreased adrenal responsiveness to infused angiotensin II (AII) to assess their responsiveness to other aldosterone secretagogues, ACTH and potassium, which are thought to stimulate aldosterone synthesis in sites different from one another and from AII. All subjects, following sodium restriction, received an infusion of AII in increasing doses (0.1-3 ng/kg per min...
متن کاملEffects of circadian rhythms, posture, and medication on renin-aldosterone interrelations in essential hypertensives.
BACKGROUND The aldosterone-to-renin ratio (ARR) is frequently used to screen primary hyperaldosteronism. This study, part of a clinical trial, was designed to measure the influence of circadian rhythms, antihypertensive drugs, and body posture on plasma renin, on aldosterone, and on their interrelation. METHODS In a prospective, randomized, open-label, parallel-designed protocol, 57 essential...
متن کاملAge dependence of the levels of plasma norepinephrine, aldosterone, renin activity and urinary vanillylmandelic acid in normal and essential hypertensives.
In the present study the upper reference limits (URLs) for resting plasma norepinephrine, epinephrine, serum aldosterone, plasma renin activity, aldosterone/renin activity ratio, as well as urinary vanillylmandelic acid in healthy Egyptian normotensive subjects over a range of ages (5-60 yr) were established. There was a significant age effect on plasma norepinephrine, UVMA, serum aldosterone a...
متن کاملEssential hypertension and aldosterone.
MANY FACTORS have been implicated in the etiology of essential hypertension and at present the primary cause of this disease remains obscure. The relationship of sodium to the development of hypertension and the question of involvement of the adrenal cortex has been the subject of numerous investigations. Efforts by earlier investigators to show a hypersecretion of corticosteroids in this condi...
متن کاملAssociation analyses of S(A) gene variant in essential hypertensives.
A gene designated S(A) has been implicated in hypertension (HT) in rat genetic models and Japanese HT patients. However, a linkage study in whites was negative. Because of the limitations of genetic analyses, confirmation in different settings is imperative. Therefore, we conducted a cross-sectional case-control study involving 106 HT and 96 normotensive (NT) white subjects. A polymerase chain ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation Research
سال: 1981
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.49.3.627